Introduction: -Globally nausea and vomiting during pregnancy is the most common medical condition, affecting pregnant women. Hyperemesisgravidarum is a condition of intractable vomiting during pregnancy, leading to fluid, electrolyte and acid–base imbalance, nutrition deficiency and weight loss often severe enough to require hospital admission. The incidence of HEG vary from 0.3 to 1.5% of all pregnant women,with most authors reporting an incidence of 0.5%. Hyperemesisgravidarum has been associated with both maternal and fatal morbidity.Clinical and social impact of hyperemesis gravidarumcan be immense, it can cause serious maternal morbidity or even maternal death There is limited evidence about proportion of hyperemesis Gravidarum and associated factors in the study area. Objective: -The aim of this study was to determine the proportion Hyperemesis Gravidarum and associated factors among pregnant women admitted to obstetric ward at Debre tabor comprehensive specialized hospital, South Gondar Zone, Ethiopia 2022. Method: - Institutional based cross-sectionalstudy design was conducted among 355 pregnant mothers. Chart review in Debre Tabor comprehensive specialized hospital, South Gondar from september1/2016- September 1/2021.systematic random sampling technique was used to select the sample and chart review were used to collect the data. Bivariable and multivariable logistic regression analysis were used to assess the association between dependent and independent variable. A 95 % CI and p –value of < 0.05 was used to measure the statistical significance of association. Result: Around one tenth of pregnant women 38(10.7%) were diagnosed with hyperemesisgravidarum.previous history of hyperemesisgravidarum (95%CI) = 4.960[3.636, 5587.6], family history of hyperemesisgravidarum (95%CI) = 4.57[3.880, 2406.335], multiple pregnancy(95%CI) = 3.034[1.788,241.328] and gestational age less than 13 weeks (95% CI) = 5.646[36.004, 2224.736] were associated with hyperemesisgravidarum. Conclusion:The overall hospital rate of hyperemesisgravidarum at Debre tabor comprehensive specialized Hospital was high which was considered to be high as compared to the universal prevalence. The risk factors of hyperemesisgravidarum were previous history of hyperemesisgravidarum, family history of hyperemesisgravidarum, multiple pregnancy and gestational age less than thirteen but may not be generalized to the general population.