Background: Trachoma is an eye disease caused by bacteria called Chlamydia trachomatis. This infection causes papillary and/ or follicular inflammation of the tarsal conjunctiva, which is referred to as active trachoma. Active trachoma prevalence among 1 to 9 years old children is 27.2% in Fogera district (study area). Many people still require implementation of the face cleanliness components of the SAFE strategy. Even if face cleanness is the important component to prevent trachoma, there is limited research done on this area. Therefore, the purpose of this study is to assess behavioral responses for face cleanliness messages. Objectives: To assess behavioral responses for face cleanliness messages to prevent trachoma among mothers having children age 1 to 9 years old. Methods: community based cross-sectional study was conducted with the guidance of extended parallel process model in Fogera District from December 01 to December 30, 2022. Multi stages sampling technique was used and 611 study participants were involved. Interviewer administered questionnaire was used to collect the data. Descriptive statistics were computed. Bivariable and multivariable logistic regression analysis were run to identify predictors of behavioral responses using SPSS V.23. Significant variables were declared by AOR at 95% confidence interval and a p-value <0.05. Result: Among the total participants, 292 (47.8%) were in the danger control. Residence [AOR=2.91; 95% CI:(1.44-3.86)], marital status [AOR=0.79; 95% CI:(0.667-0.939)], level of education [AOR=2.74; 95% CI:(1.546-3.65)], family size [AOR=0.57; 95% CI:(0.453-0.867)], round trip to collect water [AOR= 0.79; 95% CI:(0.423-0.878)], having information about face washing [AOR=3.79; 95% CI: (2.661-5.952)], Source of information (health facility[AOR=2.76; 95% CI:(1.645-4.965)], school[AOR=3.68; 95% CI:(1.648-7.530)], health extension workers[AOR=3.96; 95% CI:(2.928-6.752)], Women development army[AOR=2.809; 95% CI:(1.681-4.962)]), knowledge[AOR=2.065; 95% CI:(1.325-4.427)] self-esteem[AOR=1.013; 95% CI:(1.001-1.025)], self-control[AOR=1.132; 95%CI:(1.04-1.24)], and future orientation[AOR=2.16; 95% CI:(1.345-4.524)] were found to be statistically significant predictors of behavioral response. Conclusion: Less than half of the participants were in the danger control response. Residence, marital status, level of education, family size, face washing information, source of information from health facility, health extension workers, schools and women development army, knowledge, self-esteem, self- control and future orientation were independent predictors of face cleanliness. Strategies of face cleanliness message should give high attention for perceived efficacy with consideration of perceived threat. Key Words: Trachoma, Face Cleanliness, Behavioral Response, Extended Parallel Process Model.