Background: District health information system is an open and globally distributed system. Its data on the causes of consultation and hospitalization, services, and patient clinical outcomes are collected, analyzed, and reported by health providers and facilities. The low intention to use health information technology is attributed to the interaction between humans and technology. DHIS 2 is an aggregated statistics component of the HMIS. In developing countries, factors such as resource supply, education and training as well as management support influence the intention to use DHIS2. Objectives: To assess the intention to use district health information systems and its associated factors among health professionals in health centers of Bahir Dar Metropolitan city, Ethiopia, 2022. Methods: An institution based quantitative cross-sectional study design was employed among 368 randomly selected health professionals. Four point Likert scale Questions were used and compute to measure the outcome variable. Data were collected using structured and self-administered questions. Completed questionnaires were entered and coded into Epi-data version 4.6 computer programs and exported to SPSS version 25 for further cleaning and statistical analysis. The bivariable and multivariable outputs were summarized by the Crude Odds Ratio (COR) and Adjusted Odds Ratio (AOR). Finally, the variable which showed statistical significance (p-value <0.05) in multivariable analysis was considered as an important determinant of the outcome variable. Results: Out of 368 total samples, 342 were responded with a response rate of 92.93%. From the respondents, 176(51.5%) were female and more than one thirds, 147(43%) of the study participants were nurses. About 223(65.2%) of the study participants have an intention to use DHIS2. Among the respondents 64% (AOR=0.36, 95% CI=0.17- 0.76) had unfavorable attitude and the health professionals computer skill were 3.36 odds (AOR=3.36, 95% CI= 1.83- 6.09). Conclusion& recommendation: This finding showed that attitude, perceive usefulness, perceive easiness and computer skill were directly affect the intention to use DHIS2. A huge effort is needed to improve their computer skills before the actual implementation of DHIS2 for health professionals. In particular, 34.8% of health professionals had no intention to use DHIS2. Key words: Intention to use, District Health Information System 2, Primary Health Center