Background: Psoriasis is a common immune-mediated papulosquamous inflammatory skin disease characterized by well-demarcated, erythematous silvery scaly plagues. Prevalence rates of psoriasis showed a worldwide variation and have been reported to range between 0.09% and 5.1%. It has been associated with several intrinsic as well as extrinsic factors and has a detrimental effect on health-related quality of life. Studies on the proportion and factors associated with psoriasis are limited in the study area. Objectives: To assess the proportion and factors associated with psoriasis patients among patients who attend the dermatology clinics at Tibebe Ghion specialized and Addis Alem primary hospitals, Bahir Dar, Northwest Ethiopia, 2022. Methods: Institution-based cross-sectional study was conducted among 318 patients who attended dermatology clinics at Tibebe Ghion specialized and Addis Alem primary hospitals, Bahirdar, Northwest, Ethiopia. Data were collected using structured interviewer-administered questionnaire. Collected data were entered and coded into EPI data version 3.1 and then exported to SPSS version 27 for analysis. Patients’ characteristics were summarized using descriptive statistics and factors associated with psoriasis were identified by binary logistic regression. Result: The mean age of participants was 22.5 with a standard deviation (SD) of 18.2 years. The proportion of psoriasis was 5.3% (95% confidence interval (CI) (3.1%, 8.4%). The majority (88.2%) of psoriasis patients had plague-type morphology. Seven (41.2%) psoriasis patients had a large negative effect on their quality of life. Stressful life events (AOR= 3.32, 95% CI (1.12, 9.86) and alcohol consumption (AOR= 3.73, 95% CI (1.03, 13.51) were significantly associated with psoriasis. Conclusion and Recommendations: The proportion of psoriasis is significant in our healthcare setting to demand public health intervention. Stressful life events and alcohol consumption were significantly associated with episodes of psoriasis. Therefore, appropriate screening for alcohol consumption with strategies to limit intake and addressing psychosocial aspects should be discussed with patients. Keywords: Ethiopia, Psoriasis, Prevalence, Associated factors