Back ground: Bullet related bacterial wound infection is a type of infection caused by high velocity bullets and shrapnel injuries as well as trenches populations. In Ethiopia, significant injuries were reported that could result in persistent infections and severe wound infections may lead to amputation and mortality. The magnitude, antimicrobial susceptibility profiles and factors associated with bacterial wound infections among patients with bullet related injuries is not yet studied at health facilities in Bahir Dar, Northwest Ethiopia. Therefore this study was proposed to fill the information gap on the prevalence and antimicrobial susceptibility profiles and factors associated with bacterial wound infections among patients with bullet related injuries Objective: The main objective of this study was to determine the prevalence, bacterial profiles, antimicrobial susceptibility profiles and factors associated with bacterial infections among patients with bullet related injuries at selected health facilities in Bahir Dar, Northwest Ethiopia Method: A Hospital based cross sectional study was conducted among patients with bullet related injuries at selected health facilities in Bahir Dar from May 25 to July27, 2022. A total of 384 patients with bullet related injuries were included in the study. Sociodemographic and clinical data were collected using structured questionnaire. Wound swabs were collected aseptically and cultured on Blood and MacConkey agar following bacteriological standards. Biochemical tests were performed to differentiate bacteria for positive cultivation and antimicrobial susceptibility profiles of the isolates were done on Muller Hinton agar using Kirby- Bauer disk diffusion technique according to the 2021 Clinical Laboratory Standard Institute (CLSI) guideline. The data were entered using Epi-Info version 7.3 and analyzed using SPSS version 25. Descriptive data was presented using frequency, percentages, figures and charts Logistic regression was carried out to identify factors associated with bacterial wound infections. P-value < 0.05 was considered statistically significant RESULT: A total of 384 specimens were collected from bullet related injured patients from May 25, 2022 to July 2, 2022. The prevalence of bullet related bacterial wound infection among three hospitals in Bahir Dar city was 54.7%. The most common Gram negative organism isolated were Klebsiella spps 49 (23, 3%) and among Gram-positive cocci Staphylococcus aureus 58(27. 6%) and coagulase negative staphylococci (CONS) 18(8.6%). Among the Gram-positive cocci, the most frequently isolates were Staphylococcus aureus 58(27.6%).Hospitalization, contamination and smoking habit were significantly associated with the presence of bullet related bacterial wound infection . There were 97.6% MDR bacterial isolate. Among the isolates, E.coli, Proteus species, Citerobactor and Staphylococcus aureus were high drug resistance CONCLUSION: High prevalence of bullet related bacterial wound infection was reported in this study. The most commonly isolated bacteria were S. aureus followed by Klebsiella spps. High frequency of resistance to Ampicillin, Oxacillin, Cefepime, Ceftriaxone, Ceftazidime, Vancomycin, and Norfloxacin Therefore, proper manipulation of bullet injuries, prompt investigation of bacterial infections, monitoring of drug sensitivity patterns and proper antibiotic usage are critical. Key words: Bullet-related wound Infection, Antimicrobial susceptibility Profile, Risk factors