Introduction: Workplace violence is an all-too-common occurrence among health-care workers. Violence is a significant concern for healthcare providers, particularly nurses around the world. Nurses, who are a crucial part in the healthcare system, were among the most common victims of workplace violence. However, in developing countries like Ethiopia, the workplace violence issues are not given emphasis. Objective: the main aim of this study was to assess the prevalence of workplace violence and its associated factors among nurses working at central Gondar public hospitals, Northwest Ethiopia. Methods: A hospital based concurrent mixed method study was conducted at central Gondar public hospitals from May 09/2022 to June 08/2022. After proportional allocation, simple random sampling technique was performed to select the final 473 study participants. A self-administered questionnaire was used for data collection. The collected data was entered, cleaned, coded, and analyzed by SPSS version 25.0. Both bi-variable and multivariable logistic regression analysis were used to assess the association between independent and outcome variables. Finally, the statistical significance was set at P < 0.05. The total sample size of qualitative data were twelve nurses by selecting two nurses from each study area. Participants for in-depth interview were selected purposively. Results: The proportion of workplace violence among nurses while at work over the previous 12 months was 36.6%. Physical, verbal, bullying/mobbing, and gender-based violence were mentioned by 8.6%, 24.8%, 20.3% and 6.5% of the study participants, respectively. Major perpetrators like patient relatives, colleagues and patient themselves were identified. The findings of the qualitative component supported the results of quantitative data. Shortage of nurse staffs, drugs and medical supplies, lack of training, and inadequate security staffs, absence of reporting procedures, hospital rules and regulation were described as the main factors of violence during in-depth interview. Conclusion and recommendation: Higher proportion of workplace violence was observed among nurses in this study. work experience, institution type, work department, numbers of nurses working the same shift, and training were significantly associated with multi-variable analysis, with a p-value of 0.05 at 95 % confidence interval. Accordingly, nurses require violence prevention training to handle violent behaviors effectively. Therefore responsible bodies should design a mechanism to avoid predisposing factors to improve patient satisfaction, and thereby to reduce workplace violence. Keywords:-workplace violence, nurses, Central Gondar, Ethiopia