Background: Implanon is an effective single-rod progesterone-releasing contraceptive, preventing unwanted pregnancy within 3 years of use.Method discontinuation has a significant impact on overall fertility rates, unintended pregnancies and induced abortions. Therefore, this study is aimed to assess Implanondiscontinuation and its associated factors among women who requested removal of Implanon in Dessie town, health institutions. Objective: To assess Implanon discontinuation and its associated factors among women who requested removal of Implanonin Dessie town, Northeast Ethiopia, 2021. Methods: A facility-based cross-sectional study was conducted among 340 women who were selected by systematic random sampling technique. Data were collected using an interviewer-administered questionnaire from February 25 to April 25, 2021.EpiData Version 4.6.0 and SPSS Version 25 were used for data entry and data analysis respectively. Both bi variable and multi variables logistic regression was done to identify factors associated with Implanon discontinuation and p-value < 0.05 and 95% confidence interval were considered statistically significant. Results:A total of 29% (95% CI: 23.9, 34.0) of who requested removal of Implanon discontinued the method before theintended time period. Having history of chronic illness (AOR=2.78, 95% CI (1.325, 5.86)Parity (AOR =3.51, 95% CI (1.18, 10.46) and did not obtained counseling(AOR =6.74, 95% CI (2.461, 18.507) were found to be statistically significant factors with Implanon discontinuation. Conclusion and Recommendation: Implanon discontinuation among women who requested removal of Implanonwas relatively lowas comparedto those reported by other investigators.Butit is still a public health problem.Therefore, to improve Implanon retention, strengthening the family planning counseling service and screening of chronic illness as well as giving appropriate care and treatment for these women with chronic medical condition are recommended. Keywords: Discontinuation, Implanon, Dessie, Ethiopia