Background: Globally, critical illness causes up to 45 million deaths every year, especially the burden is highest in low-income countries. Sub-Saharan Africa bears a disproportionate high global burden of disease compared with the rest of the world. Although some studies were conducted on prevalence and associated factors of intensive care unit mortality in Ethiopia, still there are limited data on factors associated with mortality among intensive care unit admitted patients in Ethiopia including the study area. Objective: To assess the magnitude of mortality and its associated factors among patients admitted in intensive care unit of Injibara General Hospital, Awi Zone, Ethiopia, 2021 Methods: An institution based retrospective cross-sectional study was conducted between September/10/2021 to October/10/2021, simple random sampling was employed to select sample size of 422. Data were collected through pre tested data collection checklist by trained data collectors. Data were coded and entered in to Epi data version 3.1. Then cleaned and exported in to SPSS version 20 for analysis. Bi variable and multivariable logistic regression analysis were employed. Variables having P-value < 0.25 during bi-variable analysis were entered into multivariable analysis. Finally, adjusted odds ratio with 95% Confidence Interval at p-value < 0.05 was considered as statistically significant. Results: Total patients participated were 421 with a response rate of 99.7%, the overall intensive care unit mortality was 37.8% with (95%CI:33-42). In the multivariable analysis patients age 20-40years(AOR=1.13,95%CI:1.1-3.79), >60years(AOR=3.1,95%CI:1.68-6.6), time of admission (AOR=2.13, 95%CI:1.32-3.43), NG tube feeding (AOR=0.29, 95%CI:0.17-0.48), inotropes support (AOR=0.086, 95%CI:0.04-0.16) and length of stay >14days (AOR=0.27, 95%CI: 0.1-0.74) were showing statistically significant association with intensive care unit mortality. Conclusions and recommendations: The overall mortality was high and age, time of admission, tube feeding, inotropes support and length of stay were shown statistically significant association with intensive care unit mortality. Therefore, improving tube feeding, giving inotropes timely to decrease mortality among critically ill patients admitted to intensive care unit. Key words: Intensive care unit, Length of stay, Mortality, Re-admission and time of admission