Background: The World Health Organization currently encourages enhanced adherence counseling for human immunodeficiency virus seropositive people with a high viral load count before a treatment switch to the next regimen. Those who had viral load >1000 copies/ml better to get enhanced adherence counseling for 3 to 6 months before switching the therapy to the next regimen. Unsuppressed viral load count is associated with decreased survival and increased human immune deficiency virus transmission. Yet, on the contrary of enhanced adherence counseling program most of the countries fail to achieve expected level of viral load suppression. However, little is known about predictors and the magnitudes viral load suppression after the enhanced adherence counseling in Ethiopia and in the study area. Objective: This study aims to assess the proportion of viral load suppression and its predictors among human immune deficiency virus seropositive people who receive enhanced adherence counseling at public health institutions in Bahir Dar, Northwest Ethiopia 2021. Methods: An institution-based retrospective follow-up study was conducted from January 2017 to December 2021 among randomly selected 546 clients on Enhanced Adherence Counseling at public health facilities in Bahir Dar city. The data were collected with a pretested checklist by using Epicollect5 mobile application and exported to Stata version 14 for analysis. Log-Binomial regression model was fitted for each explanatory variable. Variables having a p-value <0.25 in bivariate analysis was entered to a multivariable Log-Binomial regression model. Finally, an adjusted risk ratio with a 95% confidence interval and p-value <0.05 was used to measure the strength of prediction. Results: A total of 312(57.1%) individuals were having suppressed viral load after Enhanced Adherence counseling. Absence of recurrent OI (ARR 1.40; CI 1.03-1.91), less than 3 month stay on EAC (ARR 1.54; CI 1.19-1.99), 3-6 month stay on EAC (ARR 1.38; CI 1.12-1.69), once per day ARV dose regimen (ARR 1.28; CI 1.03-1.58), baseline viral load ≤2879.00 copies/ml (ARR 1.30, CI 1.06-1.60), being orthodox Tewahido Christian (ARR 0.37; CI 0.18-0.75) were significant predictors of viral load suppression after Enhanced Adherence Counseling. Conclusion and Recommendation: Most importantly, this study find that the majority of participants had suppressed viral load after enhanced adherence counseling. Recurrent opportunistic infection, length of stay on EAC, ARV dose regimen per day, baseline viral load, and religion were significant predictors of viral load suppression. During EAC sessions, special attension should be given for clients with too high baseline viral load and who had recurrent opportunistic infection. Keywords: Viral load suppression, Enhanced adherence counseling, HIV, Ethiopia