The main purpose of this study was to examine the effects of aerobic and flexibility training on students with physical disabilities’ selected fitness variables in some selected preparatory schools at Kolladiba town in the Central Gondar Zone in the Amhara National Regional State. The research used a quasi-experimental design to conduct the study. The study involved 37 sampled students with physical disability; such as musculoskeletal problems /upper and lower limb/ and visual and hearing impairments, from preparatory schools, of whom 17 were organized into an experimental group who performed 3 days a week for 2 and half months of common and modified aerobic and flexibility training like walking, jogging, rope jumping, running, curl-ups, pull-ups, sit and retch, trunk left, toe touch, as well as dynamic stretching exercises by using strings, cones, cards, and flags; alarms or bells; and 20 were organized into the control groups using a conventional way. Data was collected using pre and post field-based fitness tests and statistically analyzed. To do so, the descriptive analysis technique was used, using mean scores and standard deviations to the mean scores of each of the field-based fitness tests, as well as an independent and paired sample t-test was applied to determine whether there was a statistically significant difference between the mean scores. As t-test analysis techniques. The result showed a statistically significant difference between the experimental and control groups in the post significance value of body composition P = .030 < .05; aerobic capacity VO2 max (12 minute cooper test) P = .000 < .05; abdominal strength (curl up test in 1 minute) P = .019 < .05; flexibility (sit and reach test)- on the right side leg P = .006 < .05 and on the left side leg P = .001 < .05; These findings showed that field-base fitness practices for students with disabilities can improve their test scores. Generally; the present study concluded that aerobic and flexibility training had a significant effect on students with physical disability physical fitness. Hence; aerobic and flexibility training was effective and beneficial effect for the enhancement of students with physical disability fitness level.