Background: Postpartum hemorrhage defines as cumulative blood loss greater than or equal to 1,000 mL or blood loss accompanied by signs or symptoms of hypovolemia after the birth process regardless of route of delivery. On my recent experiences in the hospital and other health setting in the town patients with postpartum hemorrhage was become increased and I were planned to conduct a research in this catchment area to know exact figure and to identify associated factors. Objective: To assess Post-Partum Hemorrhage and Associated Factors among mothers who gave birth at Felege Hiwot Comprehensive Specialized hospital in Bahir Dar City, North-West Ethiopia, 2022. Methods: A cross sectional study was conducted among 577 mothers who gave birth at Felege Hiwot Comprehensive Specialized hospital in Bahir Dar, Ethiopia from January 30 to June 1 2022. Study participant were selected with systematic random sampling. An interviewer administered structured questionnaire and checklist were used to collect data. The collected data was entered into Epi-data version 3.1 and exported to SPSS version 26 for analysis. Simple binary logistic regression analysis was employed to identify candidate variables at P- value < 0.25. Then multivariable logistic regression analysis was employed to identify factors associated with post-partum hemorrhage at P-value 0.05. Results: The proportion of PPH was 11.6 %( 95%CI= 9.10-14.50). Being grand multiparty [AOR= 5.80(95% CI: (2.40, 14.10)]; having a history of PPH [AOR=2.76(95% CI :( 1.27, 6.00)]; current APH [AOR=3.73(95% CI :( 1.20, 11.35)]; having twin delivery [AOR=3.77(95% CI :( 1.57, 9.03)]; developing labor abnormality [AOR=5.88(95% CI: ( 3.10, 11,10)] were factors significantly associated with the development of PPH. Conclusion and recommendation: The proportion of postpartum hemorrhage was high in the study setting as compared to WHO figure. Women with APH and twin pregnancy should be label as high risk for PPH and better to take preventive measure for them. Grand multipara and women with previous history of PPH should be followed as high risk women during intrapartum period. Key words: PPH, proportion, associated factors, and uterotonics.