The purpose of this study was to investigate the effects of 12 weeks plyometric training on selected physical fitness performance of u-17 female soccer project players at Sekela Woreda. The total subject for the study were thirty (n =30) female soccer trainees of Gish Abay Town in Ethiopia 2013 E.C. Since the study populations were little, all were taken as a sample by using comprehensive sampling technique. Through randomization method trainees segregated in to two groups, an experimental group (N=15) and a control group (N=15). The experimental group (EG) performed twelve-week moderate plyometric training, once per week for a total of 45 minutes and the control group (CG) did only their regular soccer training 3 days per week for 60 minutes duration. The data was collected through field tests (20-m sprint test for speed, T-agility test for agility and Vertical Jump test for power). The data were analyzed by using Paired sample t-test using SPSS version 25 with significance level of 0.05.Based on the analyzed data, the pre-posttest performance of EG were significantly improved thir speed in (5.32%) agility in 2.63seconds (17.6%), and vertical jump 8.5cm (19.1%). Generally, the results of this study show that 12 weeks of plyometric training improved speed, agility and power performance of u-17 female soccer project trainees. Therefore the study recommended that coaches should give concentration to plyometric training in coaching soccer and these training methods are recommended to soccer players for improving speedy and skilled performances.