Reverse logistics practice is a vital approach to enhance operational performance of the company but many organizations do not understand the benefits of reverse logistics practice on operational performance of the company. So the primary focus of this study is to analyse the effect of reverse logistics practice on operational performance in manufacturing company found in Bahir Dar Coca-Cola Company in focus. Which lead this study into the front for this study explanatory research design was employed with a sample of 176 employees through stratified sampling. A questionnaire was used as a research tool for collecting data. The collected data was analysed using both descriptive statistics (mean & standard deviation) and inferential statistics (correlation and linear regression). Main findings of the study depicts that, there is positive and significant relationship between reverse logistics practice and operational performance. Moreover, dimensions of reverse logistics practice had a significant effect of the company operational performance. Finally, the results on the conclusion entails us majority of respondents agreed to the fact that the company reverse logistics practice is good in terms of (reusing, recycling, remanufacturing, repackaging) and there is also a good operational performance in terms of (cost, quality, flexibility and delivery). Moreover, from the results it can be concluded that there is strong and positive relationship between the reverse logistics practice and operational performance of the company.