A. africanus is a traditional medicinal plant which has been widely used in herbal medicine. In this study, two different antioxidant activity quantification methods:2,2-diphenyl1 picrylhydrazyl radical scavenging (DPPH) and Ferric reducing antioxidant power(FRAP) including total phenolic content(TPC) and total flavonoid content(TFC) assays of crude extract of A.africanus root were performed. The extracts showed a significant antioxidant activity in all assays at a concentration dependent manner.The maximum total phenolic content of methanol and total flavonoid content extract was 493 and 455.45 mg GAE/ g dry samples respectively. The antioxidant activities of methanol root extracts of A. Africans were screened using 2,2,-diphenyl 1 picrylhydrazyl and ferric reducing power assay. The results showed that the methanol extract o f the root exhibited the high antioxidant capacity 62.47% percentage of inhibition at high concent ration in DPPH with 44.61mgAAE/100g total antioxidant. In FRAP assay 59.36% percentage of reducing power at high concentration with 278.16 mg AAE/100g total antioxidant. Strong correlation of TPC with DPPH (R=0.9745) and FRAP(R=0.96652), respectively) were observed. This implied that compounds in the extract were capable of scavenging the DPPH free radical and reducing ferric ions. The free radical scavenging activity and reducing capacity of the extract in the study suggest its antioxidant potential. Qualitative phytochemical content of the crude extracts obtained from the of the plant indicated the presence of alkaloids, flavonoids, phenols, g lycosides, terpenoids and tannins. Antimicrobial activities evaluation of crude extract against Staphylococcus aureus, streptococcus pyrogens (gram positive bacteria), Escherichia coli, Pseudomonas aeuroginosa (gram-negative bacteria) were showing a higher antimicrobial activity of the crude extract. The findings of this study support the view that A. africanus plant is a promising source of potential antioxidants and may be effective as preventive agent in the pathogenesis of some diseases.