Introduction: Hyperthyroidism is a medical condition of excess thyroid hormone in the blood that affects the work of thyroid gland. In addition to the health effect, it affects individuals, households, and healthcare systems financially. Globally billions of dollars cots for hyperthyroidism .A health care cost causes financial hardship hinder the household to spend on basic items and may push in to poverty. In Ethiopia, there are studies conducted on the prevalence of hyperthyroidism but its economic burden was not well studied. Hence needs this study. Objectives- This study aimed to assess the economic burden and associated factors of Hyperthyroidism patients at Debre Tabor comprehensive specialized hospital, 2021 Methods – Institutional based cross sectional study was conducted on 404 study participants were selected by systematic random sampling method from January 1 to March 30, 2021.Method of costing was prevalence approach with patient perspective. Direct costs estimated with micro costing bottom up approach and indirect costs were estimated with human capital approach method. Then Aggregated Total costs .The 10% threshold level used for catastrophic health expenditure of hyperthyroidism. To measure impoverishment poverty head count & poverty gap index before and after was calculated and World Bank poverty line (1.9 USD per day per person) was used. Data were collected using structured questioners, entered in Epi data V.4.62 exported to SPSS V-20 and Logistic regression analysis were performed at p-value 0.05, 95% CI. Results- The proportion of catastrophic health expenditure and overshoot and Mean positive over shoot at 10% threshold is 95% and 38.9% and 40.9% respectively. Prepayment head count of impovershment is 71.3% and the post payment head count is 90.2. The prepayment and post payment poverty gap is 44% and 56 % and the pre and post payment poverty gap index is 49% and 62 % respectively. Hyperthyroidism patients who has low level in education were 1.396 times more likely to spend for hyperthyroidism health care expenditure (AOR =1.396, 95% CI: 1.014-1.921) and AOR =2.266, 95% CI: 1.660-3.092) respectively than whose education is diploma and above. Conclusion –Hyperthyroidism imposes high economic burden to the patients and the households. Educational status of patient and house hold leader and family size were main predictors of catastrophic health expenditures. Key word: Catastrophic Health Expenditure, Impoverishment, Hyperthyroidism