Background Scabies is a contagious skin infestation caused by a mite known as Sarcoptes scabiei variety hominis.It affects all age groups. There is limited epidemiological data on scabies. This phenomena makes scabies neglected disease. It’s difficult to request supplies in every level due to little epidemiological data about scabies. Objective: the aim of this study was to determine prevalence and associated factors of scabies in North Mecha District, West Gojjam Zone, North West Ethiopia 2019. Method: Community based cross-sectional study design was conducted from September 01/09/2019 to October 30/10/2019. A total of 551 samples was selected and included by using multistage sampling techniques. Skin examination was done by trained health personnel to rule out clinical features of scabies. Primary data was collected by trained data collectors using pre tested semi structured questionnaires by face to face interview. Data was coded and entered into Epi data version 3.1then exported to statistical package for social sciences version 23 software for analysis. Descriptive statistics describes the population in relation to determinant variables. Bivariate and multivariate analysis was used to identify factors associated with scabies. Statistical significance was determined at p-value < 0.05. Result A total of 551 study participants were participated in the current study. The prevalence of scabies was 14.9 %( 82/551)[95%CI, (12%-18%)]. Participants with age < 15 years more prone to scabies (AOR=3.666, 95%CI: 1.970-6.824) Family size>5(3.383, 95%CI: 1.583-7.228),travelling history to scabies epidemic area (AOR=5.58895%CI: 2.213-14.112), sharing clothes with scabies cases (AOR=3.321, 95%CI: 1.452-7.595), frequency of bathing (AOR=2.715, 95%CI: 1.034-7.125), frequency of washing clothes (AOR=2.180, 1.147-4.144) and frequency of changing clothes (AOR=5.709(1.882, 17.321) were independent significant factors associated with scabies infestation. Conclusion Scabies was a public health problem in north mecha community. age less than fifteen, family size five and above, travelling history to scabies epidemic area in the last two months, sharing clothes with scabies cases, frequency of bathing, frequency of washing clothes and frequency of changing clothes were independent significant factors. Key Word: Scabies, prevalence and associated factors.