Background: -Measles is a highly infectious disease caused by a virus. It remains an important cause of death among young children globally, despite the availability of a safe and effective vaccine. More than 95% of measles deaths occur in countries with low incomes and weak health infrastructures. According to mini EDHS 2019 Fifty nine percent of 12-23 months children received measles conjugated vaccine 1 and 9% of children age 24-35 months received the second dose of the measles vaccine. Objectives:- Assess proportions of measles conjugated vaccine 2 and associated factors among 24-35 months of age children in North Mecha district, west Gojjam zone, North West Ethiopia, 2020. Methods: - Community based cross-sectional study design was conducted from July 2020 to January 2021. A total of 424 samples were selected and included by using multistage sampling techniques. Primary data was collected by trained data collectors using pre tested questionnaires by face to face interview. Data was coded and entered into SPSS version 23 software for analysis. Those variables found less than 0.2 p-values bi variable analysis were entered into multi variable Logistic regressions to identify statistically significant independent factors when the effect of other variables is adjusted. Adjusted odds ratio at 95% CI and p-value of less than 0.05 are presented. Results: Four hundred twenty two mothers were interviewed, giving a response rate of 99.5% and from the total, 53.08% were vaccinated measles conjugated vaccine 2. Women who had educational statues college and above [AOR=9.45; 95% CI (1.25-10.28)], Children born in health institutions [AOR= 4.13 ;95%, CI: (1.092-15.618)], Women who were informed of measles conjugated vaccine 2 by health extension worker [AOR=3.71;95%, CI: (1.748-7.890)],women/caregiver Know about schedule of MCV 2 [AOR: 9.14, 95% CI: (4.42-18.88)] and Travel time to Nearest Vaccine site (in walk time) ≤30 minute [AOR: 6.7, 95% CI:(2.99-15.00)] were positively associated with utilization of measles conjugated vaccine 2. Conclusion: The MCV2 coverage in the District was low. Keywords: - Measles conjugated vaccine 2, 24-35 month age children, associated factors, and North Mecha district.