Background: After six months, breast milk is no longer adequate to meet the nutritional needs of infants and children. Thus, additional complementary food should be started. Minimum acceptable diet (MAD) has tremendous health and nutrition benefits but only 12% of Ethiopian children's feeding practices meet its standards. The Ethiopian government has recently increased efforts to expand irrigation, which, if implemented well, could complement plans to eradicate malnutrition. Objective: The aim of this study was to compare the magnitude of minimum acceptable diet practice and associated factors among children aged 6-23 months in households with irrigated land users and non-users of North Mecha district, Northwest Ethiopia, 2021. Methods: A community-based comparative cross-sectional study was employed among 824 mother-child pairs aged 6-23 months, from September 15, 2021, to October 14, 2021. The sample size was determined using double population formula with the assumptions of 80% power and 95% confidence level. A stratified sampling technique was used to select irrigated and non- irrigated kebeles and the study population. A semi-structured and pretested questionnaire was used to collect data. Data were collected by face-to-face interview method. Bivariate and multivariable logistic regression analyses were used to see the association between minimum acceptable diet and independent variable at P-value <0.05 with 95% CI. Adjusted odds ratio along with a 95% confidence interval was used to assess the strength of the association. Result: There was a significant difference in magnitudes of MAD practice among irrigation land users and non-users (X2 =13.91, P<.001). The magnitude of recommended MAD practice was 28.0 % (95% CI: 23.7, 32.4) among users and 16.8% (95% CI: 13.2, 20.7) among non-users. Involvement in a decision (OR=4.37), initiation of BF (OR=5.29), and history of illness (OR=4.10) were independent predictors of MAD practice among users whereas involvement in a decision (OR=4.71), place of delivery (OR=2.51), PNC follow up (OR=3.01), and GMP service utilization (OR= 4.64) were the independent predictors among the non-users. Conclusion: The overall prevalence of the MAD practice in the study area was low compared with national and WHO recommendations. But the practice was much higher in irrigated users than in non-irrigated users. Involvement in a decision, place of delivery, PNC, and GMP are independent predictors of MAD in children from non-irrigated households. Therefore, the government should expand access to irrigation to households to improve their child's minimum acceptable diet practices.