Background: Water security is the capacity of a population to safeguard sustainable access to adequate quantities of acceptable quality water for sustaining livelihoods, human well-being, and socio-economic development, for ensuring protection against water-borne pollution and water-related disasters, and for preserving ecosystems in a climate of peace and political stability Ensuring safely managed water for every household is one of the goals of Sustainable Development Goal by the year. However credible evidence on households with improved water security is limited in the country particularly in Dera. Objective: This study aimed to determine the level of household water insecurity and associated factors in Dera woreda,Ethiopia. Methods: Community-based cross-sectional study was done on 640 households from March to June, 2017 in Dera Woreda, South Gondar Zone of Amhara region, Ethiopia. There are 32 kebeles (lowest administrative units) in the district, of which 8 kebeles were selected randomly. From selected kebeles, 640 households were selected using systematic random sampling. Data were collected using pretested structured questionnaire by trained data collectors. Data were manually entered to SPSS version 20.0 for cleaning and analysis. Binary multivariable logistic regression was used to identify factors associated with water insecurity in the study area. Results: In the study woreda the proportion of household water insecurity was 92% (95% CI 90 to 94%). Based on the findings the household water insecurity had no associations with socio demographic factors such as age, education, religion, family size, household income and marital status. Conclusions: This study revealed that household water insecurity was high in the study area. Hence, proper attention should be given during developing of water source to ensure the need of family members. According to the result of this finding household water insecurity had no association with socio-demographic factors Key words:- Ethiopia-Factors-Household-Water insecurity-Dera woreda