Background: Early detection of breast cancer using breast self-examination (BSE) plays an important role in decreasing morbidity and mortality due to breast cancer, which is the second leading cause of death in women worldwide. In most parts of Ethiopia access to health care services, especially comprehensive diagnostic services are very low, in some areas completely unavailable hence, individual breast-self-examination is very important. Objective: The main objective of this study is to assess predictors of breast self-examination among secondary school female teachers in Awi Zone, North west Ethiopia. Methods: An institutional based cross-sectional study was conducted in October/2019 among randomly selected secondary school female teachers in Awi zone, Ethiopia. A total of 395 secondary school female teachers were randomly selected based on proportional to the size of the number of female teachers in each school using simple random sampling technique. Self-administered structured questionnaire including socio-demographic characteristics, knowledge about breast cancer and perception of teachers on breast self examination using the Health Belief Model sub scales used as data collection instrument. Multivariable logistic regressions an analysis was used to identify independent predictors of breast self -examination performance with P < 0.05 and confidence interval of 95% considering statistically significant. Result: A total of 379 female teachers participated in this study with 95.9% response rate. Half of respondents 193(51%) have ever heard about BSE. Less than a third of the participants 27% reported that they performed BSE. In the bivariate logistic regression analysis family history of breast cancer, age, knowledge on breast cancer and BSE and all of HBM constructs were found to be associated with performing BSE. After controlling possible confounding variables in the multivariable logistic regression, knowledge about BSE practice, knowledge about breast cancer, perceived benefit and perceived self-efficacy were significantly associated with performing BSE at AOR(95%CI)knowledge about BSE 2.538 (2.036-3.165), knowledge about BC .572(.368-.888), perceived benefit1.121(1.037-1.211),and perceived self-efficacy1.120(1.041-1.205). Conclusion and recommendation: The practice of breast self-examination was found to be low. Perceived self-efficacy, perceived benefit and knowledge were significant predictors of BSE performance. Designing school based education programs to improve their awareness on early screening and improving their self-efficacy through demonstration of correct procedures on performing breast self-examination is recommended. Key words: breast self-examination, female teachers, health belief mode