BACKGROUND: Currently Ethiopia sets adolescent and youth health strategy (2016-2020) to improve reproductive health of adolescents, but current studies shows that adolescents faced different reproductive health problems like, HIV/STI, unintended pregnancy, and unsafe abortion. OBJECTIVE: To assess youth friendly service utilization and associated factors among late adolescents in Sekota town, Amhara region, North-east Ethiopia, 2020. METHOD: A community based cross-sectional study was conducted in Sekota town from March 02-27/2020 on 581 adolescents. A list of households in each kebeles having late adolescents was obtained from health extension workers. A simple random sampling technique was used. A structured and pre tested questionnaire was used to collect data. Data were cleaned, coded and entered into Epi-data version 3.1 and analyzed by using SPSS version 23 software. Bivariable and Multivariable Logistic Regression Models were fitted to identify factors associated with adolescent youth friendly service utilization. The strength of association was interpreted by using the adjusted odd ratio with its 95% confidence interval (CI). RESULT: Five hundred seventy two adolescents were participated making the response rate of (98.5%). The proportion of youth friendly service utilization was 37.4% with 95% CI (33.0, 41.3). Youth friendly service utilization was significantly associated with age group of 18-19 yrs. (AOR: 7.17, 95% CI: 4.43, 11.61), being in school (AOR: 3.80, 95% CI: 2.17, 6.68), getting pocket money for daily expenses (AOR: 1.98, 95% CI: 1.27, 3.07) and discussion with parents/guardians on youth friendly services (AOR: 2.84, 95% CI: 1.79, 4.50) CONCLUSION: Youth friendly service utilization among adolescents in Sekota town was low. Adolescents in the age group of 18-19 years, being in school student, getting pocket money, and having discussion on reproductive health issues with parents were factors significantly associated with utilization of youth friendly services. It is better to promote open adolescent parent communication on YFS, and emphasizes should be given by stakeholders for late adolescents. Key Words: Youth friendly Service, Utilization, Sekota Town, Ethiopia.