Background: Uterine rupture is a spontaneous tearing of the uterus during pregnancy or labor, resulting in serious obstetric complications. It is still a major and deadly public health problem causing maternal and neonatal mortality and morbidity in Ethiopia. Maternal mortality due to uterine rupture accounts for around 22.3%. However, there is a dearth of information about determinants of rupture of the uterine membrane in Ethiopia. Objective: To assess determinants of uterine rupture among women who gave birth at Public hospitals in Bahir Dar city Northwest, Ethiopia 2020. Methods: An institutional-based case-control study was conducted among 558 women (140 cases and 418 controls) from November 29 to December 24/2020. Participants were selected using a simple random sampling technique by using SPSS. We used the checklist to extract data from client’s logbook and client’s card. Data were entered, cleaned and coded using EpiData and exported to SPSS version 23 for analysis. Both descriptive and logistic regression analyses were performed. On bivariable analysis, variables with p-value <0.2 were kept in multivariable analysis. Variables with P-value <0.05 in the multivariable analysis were used to declare as statistically significant. The odds ratio (OR) with a 95% confidence interval (CI) was used to measure the strength of association. Result: Multi variable analysis showed that, women from rural resident (AOR = 2.5; 95% CI: 1.31, 4.80)), women who had a history of previous cesarean section ((AOR = 3.3; 95% CI: 1.6, 6.47) and abortion (AOR = 2.56; 95% CI: 1.28, 5.13)) were more likely to experience rupture of uterine membrane. Besides, women who had one to two antenatal care visits (AOR = 7.3; 95% CI: 3.7, 14.3). Women who faced obstructed labor AOR =6.8; 95% CI: 2.89, 16.14) and Women with multiparity ((Primipara (AOR=8.3 95%CI: 2.8-24.6), Multipara (AOR=10.9, 95% CI: 4.34-27.5), grand multipara (AOR=4.3, (1.03-17.98) were more likely to experience rupture of uterine membrane. Conclusion and recommendation: This study revealed that resident, number of antenatal care visits, obstructed labor, history of abortion, cesarean section, obstructed labor, and party were determinants of uterine rupture. Therefore, strengthening antenatal care service uptake may reduce uterine rupture. Moreover, more emphasis for care and support should be given to women who had a history of Cesarean section, abortion, women with multiparity, and rural women at any effort. Keywords: Uterine rupture, determinates, birth, Bahir Dar, Ethiopia