Background: Neonatal mortality is the death of newborn within 28 days of birth and it is a global critical Problem. Despite, tremendous efforts, it is unacceptably high in the Sub Saharan Africa countries including in Ethiopia. On top of that, studies on factors of neonatal mortality are scarce in Ethiopia. So investigating the factors of this crucial and obscured health problem has utmost importance in achieving sustainable development goal by 2030 (aimed to reduce neonatal mortality bellow 10 deaths/1000 live births). Objective: To identify associated factors of neonatal mortality among live births in Ethiopia, EDHS, 2016 Methods: This analysis was based on Ethiopia demographic health survey (EDHS), 2016.It is a community-based cross-sectional study. A total of 10193 (10607weighted) samples were included for current study. A Stratified two-stage cluster sampling technique was used. STATA 14 was used for analysis and data extraction. Bivariable and multivariable logistic regressions were applied. Survey (svy) design was applied to account the data nature. Adjusted OR ratio (AOR) with 95% confidence interval was reported as measure of association. Statistical significance was considered at p value<0.05. Results: The results showed that short birth interval AOR: 1.90 (95%CI, 1.02-3.52) being male AOR: 3.09 (95%CI, 1.70-5.59), multiple birth AOR: 12.68 (95%CI, 5.12-31.42) than single birth and have media access AOR: 2.88 (95%CI, 1.55-5.32) were independent predictors of neonatal mortality in Ethiopia. Conclusion: The current study identified short birth interval, male sex multiple births and have media access were independent determinants of neonatal mortality in Ethiopia. Policies and strategies better to focus on accessing spacing of children for mothers to reduce neonatal mortality. Keywords: neonate mortality, associated factors, live birth, Ethiopia.