Background: Infant and young child feeding practice is a cornerstone of care for child development mentally and growth physically. Failure of proper infant and young child feeding practice is associated with increased risk of childhood morbidity and mortality. Even, there are nutrition sensitive activities like irrigation schemes, evidence on infant and young child feeding practice among mothers living in irrigated and non-irrigated area was scarce or limited. Objective: To assess infant and young child feeding practice among 0-23 months of age children in irrigated and non-irrigated area of Dangila Woreda, North-west of Ethiopia, 2021. Methods: Community based comparative cross-sectional study was conducted from Dec 2, 2020 to January 1, 2021 with a total of 823 mothers who have infant and young children 0-23monthes of age in 9 selected Keeble’s were included in the study. Stratified sampling technic was implemented to select kebeles and systematic sampling technic was implemented to select study units. Data was collected by face to face interview method. Binary logistic regression analysis was used, variables with p<0.05, was taken as statistically significant and independently associated with infant and young child feeding practice. Adjusted odds ratio along with 95% confidence interval was used to assess the strength of the association. Result: Among 823 households visited, 802 participants gave complete responses with response rate of 97.4%. The overall prevalence infant and young child feeding practice was 72.2% (95%CI: 67.5%, 76.1%) in irrigated and 52.5% (95%CI: 47.8%, 57.4%) in non-irrigated area and out of the total was 62.5%, (95%CI: 59.1, 65.8%). Moreover, the study identified that ANC (AOR= 2.138, 95% CI: 1.085, 4.210), knowledge (AOR= 2.43, 95% CI: 1.634, 3.632), attitude (AOR= 1.687, 95% CI: 1.129, 2.520), PNC (AOR= 1.606, 95% CI: 1.154, 2.360) and women’s decision making (AOR= 1.941, 95% CI: 1.305, 2.888) were significant predictor for IYCF among 0-23months of age children. Conclusion: The overall prevalence of infant and young child feeding practice was higher as compared previous study conducted and had shown significant variation among in irrigated and non-irrigated area. Women’s decision making, ANC follow up, PNC follow up, attitude and knowledge were identified as significant predictors. The district agricultural office should extend irrigation scheme to non-irrigated area. Keywords: Dangila woreda, Irrigated kebele, non-irrigated kebele, IYCF practice