Background: - Household water treatment and safe storage interventions are proven to improve water quality and reduce diarrheal disease incidence in developing countries. Most rural population of Ethiopia did not practice any alternative water treatment methods which would pose them to high public health risks. Moreover, there are little studies pertaining to household water treatment practices and associated factors in Ethiopia. Objective-- To assess practice of house hold water treatment and associated factors in rural kebeles of Degadamot woreda, North West Ethiopia, 2020. Method: A Community-based cross-sectional study was conducted in Dega Damot Woreda, North West Ethiopia, from March20/2020-April 20/ 2020. A Multistage sampling technique was carried out to select 845 sample households in the study area. The Data was collected using pre-tested questionnaires. The data was checked for its completeness, recoded and entered to Epi- data version 3.1 and exported to SPSS version 23 for data cleaning and analysis. Multivariable binary logistic regression analysis was done to predict variables related to household water treatment practice. Result: In this study, the level of household water treatment practice at household level was found to be 119 (14.1%): [95% CI: 11.8%-16.3%]. Able to read and write [AOR: 5.81, 95% CI: 3.60-9.38], income earning >600ETB per month [AOR: 2.78, 95% CI: 1.50-5.15], no under five children in the household [AOR: 0.21, 95% CI: 0.10-.49] and pouring [AOR: 0.42, 95% CI: 0.27-.66] were factors significantly associated with household water treatment practice. Conclusion and recommendations: water treatment practice in Degadamot woreda was very low. Factors that were significantly associated with household water treatment practice were educational status, income, number of under-five children and ways to fetch drinking water. The woreda water office collaborated with woreda health office is better to deliver household water treatment methods and demonstrate them by kebeles/sub kebeles. Supporting materials needed for household water treatment practice early soon the community walked up to do so is also better to be implemented. Key words: Household water treatment, practice, Factors, Dega Damot, Ethiopia