Hot Pepper (Capsicum annum L.) is an important spice and vegetable crop in the world and in Ethiopia. It is a source of nutrition, foreign currency and cash for the smallholder farmers. However, the productivity of hot pepper is low due to unbalanced nutrient supply in the soil. Therefore, the field experiment was conducted to generate the productivity of hot pepper through application of NPS and cattle manure at different rates in combination. The treatments were consisted of four levels of blended NPS fertilizer (0, 100,200 and 300kg ha ) and four levels of cattle manure (0, 5, 10, and 15 t ha -1 ). The experiment was laid out as a Randomized Complete Block Design in a 4× 4 factorial arrangement and replicated three times. Data were collected on crop phenology, growth and yield parameters and subjected to analysis of variance using SAS computer software version 9.4. The result revealed that the main effects of both blended NPS and cattle manure fertilizer rates had significant effect on all tested parameters, while the interaction effect was significant on days to 50% flowering, days to 50% pod setting, days to 90% pod maturity, plant height, number of pod per plant, pod length and width, number of seed per pod, marketable, unmarketable and total pod yield. However, number of branch and leaf number per plant were not significantly affected by the combined application of NPS and cattle manure. The highest levels of growth parameters of hot pepper were recorded from the applications of highest rates of NPS and cattle manure fertilizer rates. The highest marketable dry pod yield (2.90 t ha -1 ) and total dry pod yield (2.99 t ha -1 ) were obtained from the combined application of 200 kg ha -1 NPS with 15 t ha CM. The combined application of 200 kg ha -1 NPS with 10 t ha -1 CM recorded the highest net benefit 615,080ETB ha -1 with acceptable marginal rate of return value 4914.29%, which can be recommended for profitable hot pepper production in the study area and areas with similar agro-ecologies. Furthermore, as the studies were conducted at one location for a single season, repetition of the study across different representative agro ecologies and seasons in the district is also recommended. -1 -1