Background: - Scabies is one of the widespread but neglected parasitic diseases and it is a major public health concern worldwide and in resource-scarce countries. Scabies affects all age groups and both sexs however, it is most common among low economic people. Objective: - To identify risk factors of scabies among the community members of Ayehu Guagussa district, Awi zone, northwest, Ethiopia, 2021. Method: A community-based unmatched case control study was conducted in Ayehu Guagussa District to identify risk factors of scabies. A multi-stage sampling technique was used. A total of 813 samples were employed using registered scabies cases and controls. Data collected by three Public health officer and five Degree holder nurse. Face to face interviewed with structured questionnaires was adminstered to collect data. Data was entered, Epi data and analyzed using SPSS 22 statistical software. Bi-variable and multivariable analyses were used to identify candidate variable for further multi-variable logistic regression analysis. Adjusted odds ratio (AOR) and 95% confidence intervals (CI) are generated to show the presence and strength of association between independent variables and scabies. Result: The mean age case 38.45±13.77 years, similarly the mean age of controls was 37.65±14.39 years. The majority of respondents 485(59.7%) were males and more than seventy present (73.9%) of respondents have had less than 5 household family sizes. Independent risk factors found to be statistically associated with scabies infestation were sex of respondants (AOR = 1.66, 95% CI: 1.10, 2.49), travling history to endemic area, ((AOR=7.657 (4.703, 3.162), blanket or cloth sharing with scabies cases (AOR= 4.753(2.373, 9.519) and home being afected by flooding ((AOR=3.026, 95% CI (1.430, 6.401)). Concussion and Recommendation: there is a positively association between scabies and respondents sex, source water, separating kitchen from reception room, habits of taking shower regularly, sharing blanket or clothes with others. Based on this the finding needs identifying the risky group for scabies and taking action, Promotions of protecting water source, separation of kitchen from reception room, taking shower regularly, and stop sharing blanket or cloths. Keywords: Scabies, case control, risk factor, community based, and Ethiopia