Background: Small scale industries are often the main pillar of an economy. Accidents, ergonomics problems, old and outdated machinery, and lack of awareness about safety practices have created a need for implementation of safety practices in small scale industry. There is scanty of information on occupational safety practices and its associated factors among small scale industry workers to take evidence-based prevention of occupational injuries intervention. Objective: To assess the level of occupational safety practices and associated factor among workers in Small scale industries in Debre Tabor town, Northwest, Ethiopia. Methods: A cross-sectional study was conduct from December 15,2020 to January 15,2021 at small scale industries in Debre Tabor town, North West, Ethiopia. Simple random sampling method was employed to select 412 study participants. Data were collected using pretested structured questionnaire. Observational checklist was also used to work through inspection to assess their working environment. Data were coded and entered in to Epi data version 4.6 and exported to SPSS version 20 for data cleaning and analysis. Bi-variable and multivariable logistic regression analysis were done to identify factors associated with the safety practices. A p value <0.05 was taken to determine significantly associated factors. Odds ratio with 95% CI were also calculated to measure the degree of association between independent and outcome variables. Result: Of 412 total samples, 406 participated with response rate of 98.5%. Of all participants 386 (95.1%) of participant were males. The mean age(±SD) of the participants was 26.64(±6.14) years. The level of occupational safety practices among small scale industry workers was found to be 77.3% with (95% CI: 73%, 81%). Taking training on occupational safety and health [AOR=3.82, 95% CI :( 1,31, 11.18)], regular supervision [AOR=5.48, 95% CI: (2.45,12.27)] and knowledge on safety practices [AOR=9.08, 95% CI: (2.63,31.43)] were significantly increased the odds of occupational safety practices. Conclusion: The level of occupational safety practices was high among small scale industry worker in the study area. The prevalence of safety practices among small scale industry workers was higher among those having good knowledge on occupational safety practices, taking training on occupational safety and health, and regular supervisions increased the odds of occupational safety practices. The identified modifiable factors are the area of intervention to increase and sustain safety practices in small-scale industries than counter parts. Keywords: Small scale industries, occupational safety practices, safety practices