Introduction: Sustainable development goal mandates to ensure equitable sanitation, end open defecation and paying special attention to needs of people in vulnerable situations. People with physical disability are under multiple challenges to benefit sanitation services as the general population. Objective: To determine latrine access and identify factors associated among physically disabled people in kombolcha town, 2020. Methods: community based cross sectional study was conducted from April first to April 20 among physically disabled people in Kombolcha town. Quantitative data was collected from 374 randomly selected study participants using structured interviewer administered questioners. Key informant and in-depth interview were conducted on purposely selected individuals. The collected quantitative data was entered into Epi-Data-version 3.1 and then exported into SPSS version 23.0 for analysis. The bivariate and multivariable logistic regressions analysis was conducted. Qualitative data was analyzed thematically through repeat reading and hearing the view of respondents Results: A total of 374 participants were included with 98.4% response rate. Prevalence of accessible latrines was found to be (22%), 95% CI (17.7-26.5) .Membership to disability association (AOR=2.162, 95% CI (1.231-3.799)), wealth status of study participants. (AOR=4.169, 95% CI (1.96-8.864)) stigma and discrimination to get latrine in last 12 months (AOR=0.212, 95% CI (0.116-0.388)) and study participant’s knowledge to construct accessible latrine (AOR=4.389, 95% CI (2.446-7.87)) were predictor variables of latrine accessibility. shared/public latrine ,stigma and discrimination, poor wealth status, homelessness and lack of information provision regarding latrine accessibility were identified as barriers for inaccessible latrine from In-depth and key informant interview. Conclusion and recommendation: latrine access among PWPDs was found to be at low . Poor knowledge of accessible latrine construction, poor wealth status, stigma and discrimination and not member of disability association increased risk of latrine inaccessibility. So, provision of trainings, income generation activities, awareness creation and join disability associations were recommended. Keywords: Physical disability, accessible latrine, Kombolcha town