Back ground: Although breast self-Examination is no longer acceptable as a standard method to detect early breast cancer, world health organization recommends breast self -examination and mammography for raising awareness of women about breast cancer. Secondary prevention through monthly breast self-examination is the best option to tackle the rising incidence of breast cancer. Breast cancer is the most common cancer among women in Sub-Saharan Africa and globally. There is limited evidence related to breast cancer screening practice among women in Ethiopia. It is estimated that only minority of women (25 to 30%) perform breast self-examination each month. Low level of awareness, lack of effective screening programs to detect breast cancer is the possible factor for the observed higher incidence and mortality rate of breast cancer in Ethiopia. Objective: the main objective of this study was to assess early detection practice of breast cancer and associated factors among women aged ≥15years in Bahir dar city from March 12 to March30/ 2020. Method: A community based cross sectional study was conducted from March 12 to March 30, 2020. The study was conducted in 10 randomly selected kebeles of Bahir Dar city. Individual households were selected using systematic random sampling. A total of 617 women were interviewed using semi-structured questionnaire. The data were checked, cleaned, and entered into EPIDATA version 3.1 software, and exported to SpSS version 23 statistical software for analysis. Both descriptive statistics-such as simple frequencies, and Analytic statistics such as bivariate and multivariable binary logistic regression analysis were used to identify candidate variables and to determine the presence and strength of association between several independent factors of early detection practice of breast cancer, respectively . Odds ratio and 95% CI for the AOR were used to find out the associations between independent variables and early detection practice of breast cancer. Hosmer and lemshow goodness of fit model and chi-square assumptions were used to check the model fitness. Results: A total of 617 respondents participated in the study with 100% response rate. From the total respondents, only 200⌠ (32.4%), 95%CI (28.5, 36.1)⌡ of them had practiced breast self-examination, 41(6.6%) mammography and 48(8%) clinical breast examination. From the total respondents, 26% had good knowledge and 45% had good perception towards breast examination. Good knowledge [AOR=5.01, 95%CI (2.84-8.82, p<0.001], good perception ⌠3.96, 95%CI (2.39- 6.55), p<0.001⌡,source of information ⌠4.09, 95%CI (2.244- 7.485), p<0.001⌡,marital status ⌠3.55,95%CI (1.841-6.687),p-value<0.001⌡,occupational status⌠ 6.25,95%CI( 2.464 -15.748),p-value<0.001⌡ and family history of breast cancer were found to be statistically significant predictors of breast cancer early detection practice. Conclusion and recommendation: BahirDar health centers should give health education for mothers at community level to improve their knowledge on early detection practice of breast cancer. Amhara health bureau and Bahir Dar city health sectors should integrate with Amhara MAs media to access information for mothers on early detection practice of breast cancer at community level. Bahir Dar city Schools should incorporate breast cancer early detection practice in their school health projects to access information for female students. Key words: practice, breast, breast cancer, early detection, associated factors.