Background: Family contacts with pulmonary Tuberculosis (TB) index case are the higher risk groups to develop TB compared with those who do not yet. However, screening rate of this risk groups reported as very low in most research reports in Ethiopia. Knowing the level of family contact screening would identify the gap of strategic implementation and uses to improve active case detection. Objective: To assess the level of family contact screening and the associated factors among Pulmonary Positive Tuberculosis Patients in South Wollo Zone, Ethiopia. Methods: Institution based cross sectional study with primary data was conducted using structured questionnaire among 403 pulmonary tuberculosis index cases of south Wollo Zone health facilities from May 1st to June 30th. Probability method of simple random sampling technique was used to select the study units after proportional allocation to health facilities. Data were collected through face-to-face interviewer administered interview. About 5% of the sample was pre tested before entering the actual data collection. The data were entered in to Epi-Info7 then exported to SPSS 23 for further analysis. Frequency tables, percentages and figures were used to describe the result. Variables with P-value < 0.2 in the Bi-variable logistic regression were included in the multivariable logistic regression and with p-values < 0.05 were considered as associated factors of the Level of family contact screening in multi variable analysis. The degree of association between independent and dependent variables was assessed using crude and adjusted odds ratio, and 95% confidence interval. Model was checked and fitted. Result: The overall level of family contact screening was 55.3%, (CI: 60, 50). The odds of having family support for care and treatment is two times more likely higher to screen their families than those who do not have (AOR=2.21, 95% CI: 1.16, 4.21. The odds of waiting time less than 60 minutes is two times more likely screen their families than those whose waiting time is more than60 minutes (AOR=2.03, 95% CI: 1.28, 3.21). The index cases who took health education on TB prevention and treatment were two times higher to screen their families than those who do not (AOR=1.86), 95% CI: 1.05, 3.29). Finally, the odds having good knowledge is three times more likely to screen their families than having in poor knowledge (AOR=2.76, 95% CI: 1.77, 4.294). Conclusion: The overall level of family contact screening was low as compared to the stated standard targets globally as well as nationally. Factors associated with the level of family contact screening in this study were family support, waiting time, health education offered by health care workers and level of knowledge of the index cases. While there, is a need of strengthening and evaluation of family contact screening activities and maximize the community awareness level on tuberculosis. Key words: Tuberculosis, Family, Contact, Screening, Ethiopia