Back ground:. Caesarean Section is a surgical intervention designed to prevent maternal and fetal complications. Maternal Mortality Rate in Ethiopia was 412/100000 live birth. Previous study focuses on comparing cesarean section in public and private hospital in specific urban area. In the best of our knowledge there is no regional level previous community based study that assess trends and associated factors of cesarean section. Objective:. The objective of the study is to assess trends and associated factors of Cesarean section in Amhara Region, Ethiopia from 2000 to 2016. Methods and Materials:. The study was based on the four Ethiopia Demographic and Health Surveys data. The surveys used a multi-stage cluster sampling technique. The data were downloaded from the official website of the Demographic and Health Survey program, after getting permission from the Demographic and Health survey team. The regional data were extracted and analyzed by using STATA version 14. Bivariable logistic regression was carried out to identify individual variables associated with the outcome variable in all the four survey and Finally, the multivariable logistic regression analysis was carried out to control confounding and identify independent variables’ having p-value <0.05 with 95% confidence interval was considered as statistically significant. The significant of trend line was cheeked by calculating the confidence interval .average annual rate of change was calculated by using formula . Result:. The rate of cesarean section was increased from 0.1% in2000 to2.3% in2016 Demographic and Health Survey. Only 0.94% of the rural women had a cesarean section compared to11.54% of the urban women. Women who had 4-6 children (AOR0.023, 95%CI 0.00237-0.2303), women who had 7ormore children(AOR,0.0048,95%CI 0.000146-0.162641), maternal age20-34 years (AOR0.046, 95%CI 0.00536-0.39402), and residence being rural (AOR 0.058, 95%CI 0.0120-0.2807) had significant Association with cesarean section. Conclusion:. The rate of cesarean section is below world health organization standards (5-15%). As maternal age increased the rate of cesarean section increased whereas cesarean section increased when parity decreased. The government should expanded cesarean section set up in the rural area to overcome disparities between urban and rural residence and should improve the service as the standard. Key words; Caesarean section, associated factors, trend analysis, Ethiopia, Amhara region