Background: Perinatal mortality is death from twenty-eight weeks of gestation to the seventh day of birth. Globally 3.3 million stillbirths and 3 million early neonatal mortality occurred every year, and 98% of mortality was in developing world. Perinatal mortality in Ethiopia was reported to be 33 per 1000 births. Despite there were numerous studies conducted in specific local area with about perinatal mortality national representative studies are scarce in Ethiopia. Objectives: To assess the prevalence and associated factors of perinatal mortality in Ethiopia using EDHS 2005 to 2016. Methods: Community based Cross-sectional study design was used. EDHS 2005- 2016 data were used to assess the prevalence and factors associated with perinatal mortality with sample of 34,428 births. Weighting has been applied to adjust the difference in the probability of selection. STATA version 14.1 was used for data analysis. Both bivariable and multivariable logistic regression analysis was used to identify factors associated with perinatal mortality in Ethiopia. Result: This study showed that perinatal mortality rate in Ethiopia was 39 per 1000 birth. Tetanus vaccination of 2+ during pregnancy decreased of perinatal mortality, whereas multiple births, caesarian delivery, birth interval less than 24 months, anemic mother, and large size at birth increased of perinatal mortality. Tetanus vaccination of 2+(AOR=0.80 ;95 % CI: 0.65 , 0.99) , multiple births (AOR =3.35; 95% CI: 2.44 , 4.61), delivered by caesarian section (AOR =2.11; 95 % CI: 1.18 , 3.76) ,having birth interval < 24 months (AOR =2.27; 95 % CI: 1.90 , 2.71) ,anemia of mothers (AOR =1.33; 95 % CI: 1.07 , 1.65),large size baby at births (AOR =1.99; 95 % CI: 1.61 , 2.46), were factors associated with perinatal mortality. Conclusion: The finding of this study showed that the prevalence of perinatal mortality was high. Tetanus vaccination during pregnancy, types of birth, birth interval, anemia of mother, size of child at birth, mode of delivery, were factors for perinatal mortality. So strengthen the existing maternal, neonatal and child health program to reduce perinatal mortality is crucial. Key word: perinatal mortality, EDHS, Ethiopia.