Background: Intention to leave is when an employee is planning to leave an organization in the near future. Measuring the intentions to leave of employees is a very strong indicator of staff turnover. Staff turnover is a major problem worldwide and especially in developing countries like in our continent Africa. Therefor knowing the employee’s intention to leave will help in identifying ways to retain health care providers. Objective: To assess the magnitude and associated factors of intention to leave among health care providers in districts of Gojjam North West Ethiopia. Method: Institution based cross-sectional study was employed from March 8 to April 25, 2020. A total of 546 health care providers were selected with a response rate of 90.1% samples were taken, self-administered questionnaires were used. Data were entered into Epi-info version 7.1 and exported to SPSS version 20 for further analysis. The logistic regression model was used to identify predictive factors for intention to leave the current organization. Factor analysis was done for the Likert scale questions, and Cronbach alpha test was used to check for reliability of the questions Result: The overall intention to leave among the professionals in the study was 57.9% (95% CI 53.7-62). Male health care providers were 1.8 (AOR: 1.844; 95 %CI: 1.254-2.712) times more likely to have the intention to leave. Being single had 2.15(2.165; 95% CI: 1.447-3.239) more likely to intend to leave than the married health care providers. Having an educational status of degree and above was found to be 1.5 (AOR: 1.52; 95 %CI: 1.040-2.222) times more likely to have intention to leave the health center than those who have only diploma. Professional who believe decisions are made by higher managers were 1.5 (AOR: 1.55; 95 %CI: 1.051-2.287) more likely to intention to leave than those who don’t. Conclusion: All over the magnitude of health care provider’s intention to leave the public health centers of districts they currently work in are high. Being male, having higher a level of educational status and Involvement in the decision-making process, being single were major contributing factors to the high magnitude. Health care providers should be involved in the decision making process and be placed in a place that fits their status to use their full potential. Keyword: Intention to leave, West Gojjam zone, health care providers and public health