Back ground: Healthcare facilities are producing wastes which have potential negatively to affect health care workers, the public and the environment if they are not properly managed due to its hazardous nature. Updating data on estimating healthcare wastes generation rate and describing its management practices are important for taking corrective action. Although, there are few studies conducted on healthcare wastes generation rate and management practices in Ethiopia they are only included urban health centers and does not considered seasonal variation so this study considered both rural and urban health centers and seasonal variation.