Background: Sanitation service access is one of the challenges faced by people with physical disabilities that limit their mobility in their home and working environments. Sanitation facilities should be designed, built and located for easily accessibility and utilization. There have been different interventions to increase the access of sanitation services by the government and non-government organizations. However, there is scarcity of information updated and widely scoped in all city administrations on sanitation services and associated factors among people living with physical disability in Amhara region city administrations.