Surface water sources are known to contain a high amount of natural organic matter (NOM) which results from natural and anthropogenic activities. The NOM could react with chlorine to produce disinfection by-products (DBPs) that are unhealthy and environmentally unfriendly. The objective of this study is to examine the effectiveness of synthetic and bio-coagulants for the removal of NOM and turbidity from raw water. Water samples were collected from the Legedadi water treatment plant in the dry (April) and wet (July) seasons of 2021. To test the effectiveness of the coagulants for the removal of turbidity a Jar test was used and revealed that optimum coagulant doses were found to be 70 & 30 mg/l for PACl, 110 & 90 mg/l for Aluminum sulfate, and 140 & 120 mg/l for MOS for dry and wet seasons respectively. Enhanced coagulation experiments were carried out to evaluate the efficiency of the coagulants to remove TOC and Turbidity. Moreover, A 3x3x3 full factorial design was used to evaluate the effect of Coagulant type, dose, and pH each with three levels to study the removal of turbidity and TOC. Enhanced coagulation removal efficiency of TOC and UV254 followed an order of PACl > Aluminum Sulfate > MOS.Coagulant dose, pH and coagulant type significantly affected the TOC and Turbidity removal from the raw water (P < 0.05). These results imply that synthetic and bio-organic coagulants can be used as a viable option in treating water to remove NOM and reduce the DBPs potential formation. Keywords: Enhanced coagulation, bio coagulant, synthetic coagulant, turbidity removal, TOC, NOM.