Two sets of experiments were conducted at Adet and Burie in 2011 main cropping season with the aim of comparing the traditional sowing practice (broadcasting) with drill method of sowing, and of determining the effect of seed and fertilizer rates on the infestation of weeds, and growth and yield of bread wheat. Totally fifteen treatments (combinations of three seeding rates and five NP fertilizer levels) were tested under factorial experiment with Randomized Complete Block Design (RCBD) at three replications. The seeding levels were 125, 175 and 225 kg/ha, and JOO, 150 and 200 kg/ha for broadcast and drill/row methods of planting, respectively. NP fertilizer levels were 92-46, 138-46, 138-92, 184-92 and 230-92 kg/ha N-P205. Plant height, stand count, tiller number, biomass and grain yield, thousand seed weight, hectoliter weight, wet gluten, grain and flour protein and SDS test were among the important data taken. Composite soil samples were also taken before planting and after harvesting from each treatment's plots. Analysis of variance (ANO VA) for all parameters was computed with SAS 12. 0 software and mean separation was done using Duncan's Multiple Range Test (DMRT). As result from Broadcast planting method indicated only the main effects of seeding rate on grain yield and weed biomass; and the main effect of NP rates on stand count, weed biomass, biomass and grain yield were significant (P<O. 05); whereas the interaction was significant (P<O. 05) for all growth and yield traits except seeds per spike , 1000 seed weight, hectoliter weight. The main effect of seeding and NP on weed biomass was only significant for drill planting method; while plant height, tiller number and grain yield were significantly (P<O. 05) influenced by the interaction. The study revealed that drill/row method of planting has 56.2 % grain yield advantage and 69. 6 % weed biomass reduction over broadcast planting. Under broadcast method of planting, a seeding rate of 125 kg/ha and fertilizer rate of 230 192 kg/ha NIP20s were found to be the best economically profitable combinations with net benefit value of 30642. 06 Birr/ha. Under drill/row planting method seeding rate of 150 kg/ha and fertilizer rate of 138 192 kg/ha NIP20s were the best profitable combinations with a net benefit value of 46071.2 Birr/ha. There was no significant difference among treatments for bread wheat quality traits. Indeed, the highest wet gluten content was found at ·the highest NP level (230 N kg/ha and 92 P205 kg/ha), whereas the lowest gluten content was found at the lowest NP combination (92 N kg/ha and 46 P205 kg/ha). Broadcast planting method gave the largest amount of weed biomass amounted 22983 kg Iha from 125 kg/ha seeding rate and 138192 kg/ha NIP205 level, while drill/row planting method the largest 14750 kg/ha weed biomass was obtained from 150 kg/ha seeding rate and 184192 kg/ha NIP205 level. In both planting methods, tiller number, stand count, spike length, biological and grain yield were found to increase linearly.pvi~k.tKte i¥ffease of NP levels, and they were found contrarily to decrease with the increase.if~<Jttii~~