Background: Low birth weight is one of the public health problems in the globe and it is an indicator of the health of the new born and the mother. Low birth weight newborn have a greater risk of illness or death, need especial care, instrument trained health personal, prolonged hospitalization, There is limited study on prevalence and associated factors of low birth weight in Tibebe Geon and Felege hiwot specialized hospitals so this study fill this gap and give base line information for Amhara region health Bureau and researchers. Objective: To assess prevalence and associated factors of low birth weight among new born with mother in Tibebe Geon and Felege Hiwot Specialized Hospitals.in2020. Method: A facility based cross-sectional study was conducted from January/1/2020 to February 31/2020 Total of 237 mothers were selected using systematic random sampling. Data were collected by using interviewer administered quantitative structured questionnaire and medical records. Data were checked for completeness, coded, and entered using Epi-Info version 7 and export to SPSS version 23 for analysis. In bivariate analysis if the variables p-value was less than 0.25 was entered into multivariable logistic regression model. In multivariable logistic regression analysis the variables which p-value became less than 0.05 were significantly associated used to determined associations between dependent and independent variables. Result: The prevalence of low birth weight was 12.7%. Maternal residence (rural) AOR= 3.2; 95% CI (1.3-9.7), mothers educational status (primary education) AOR= 3.3; 95% CI (1.2-9.3) and unable to read and write AOR= 8.9; 95% CI (1.7-48.0), sex of new born (male) AOR 2.7 (95% CI: 1.1- 6.5) were significantly associated with low birth weight. Conclusion: the prevalence of low birth weight was in line with study in Deber tabor hospital in the study area maternal residence maternal education and sex of the new born were independently associated with low birth weight. Recommendation Community awareness creation on rural residence about maternal nutrition and maternal education level by improving education access in rural residence is recommend to prevent low birth weight