The comparative study was conducted at Alage and Ardaita A TVET College to evaluate milk production and reproductive performance of Holstein Friesian dairy cows under two different agro ecologies and HF x Boran crossbred dairy cows a/ Ardaita A TVET college dairy farm. The data collected from three months monitoring study and from compiled records from 2000-2015 on milk production and reproductive traits were used for the study and analyzed using general linear model procedures of SAS version 9.2 (SAS, 2008). Three months monitoring study was conducted to obtain morning and evening milk production based on agro ecology, lactation stages, parity class, lactation months and blood level. The overall estimated least square means of morning milk yield (MMY) and evening milk yield (EMY) were 6.65±0.02 and 5.46±0.02 kg for pure Holstein Friesian cows and 5.97±0.04 and 4. 93±0. 04 kgfor Holstein Friesian and HFx Boran crossbred dairy cows. Except agro-ecology, morning and evening milk yield significantly affected by all genetic and non-genetic factors. From the collected data of compiled records, the result revealed that, the overall least square means of lactation milk yield (LMy), lactation length (LL), age at first Service (AFS), age at first calving (AFC), days open (DO), calving interval (Cl) and number of services per conception (NSC) of pure Holstein Friesian cows were estimated to 39.75±0.53 months, However, the overall least square means of LMY, LL, AFS, AFC, Holstein Friesian and Hli xHoran crossbred dairy cows at Ar 2787.35±37.64 kg, 310.59±2.89 days, 31.33±0.44 months, XIII .\