Background: Diabetes mellitus (DM) is a metabolic disorder that has been resulting from a defect in insulin secretion, insulin action, or both. The main objective of this study was joint predictors of pulse rate and time to first recovery among diabetes mellitus patients under treatment; in case of Felege Hiwot Referral Hospital Bahir Dar, Ethiopia. Method: A retrospective cohort study design was conducted on Diabetes Mellitus patients selected by inclusion and exclusion criteria at Felege Hiwot Referral Hospital under a follow-up period from April2017 to March2020. Exploratory data analysis, Linear Mixed Model for Longitudinal Pulse Rate, Cox-Proportional hazard model for survival part time to first recovery and joint model for the two response variables simultaneously linked by shared random effects were used. Results: On the sex of patients, 33.3% of the patients were male and the remaining 66.7 % patients were female. Patients with family history of disease accounted about 19 % of total patients that means the majority patients had no family history of disease. The time needed to reach first recovery among male patients was significantly longer compared to female patients. Based on the result of AIC, BIC and likelihood ratio tests joint model of longitudinal change and time to first recovery was seen to perform better than separate models. Patients’ age, residence area, other related disease, family history of diabetes mellitus, Systolic and Diastolic blood pressure were found to significant determinants of pulse rate. The estimated association parameter (α) in joint model is -1.5108 and statistically significance with (p-value<0.0001). The result indicates the higher value of Pulse Rate was associated with the lower time to first recovery. Conclusion: the variable age, residence area, other related disease and SBP were common factors for longitudinal measure of Pulse Rate and time to first recovery of DM patients. The time needed to reach first recovery among patients with no other related disease was significantly shorter compared with patients with other related disease with hazard ratio =0.0893.