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Background: Diabetes mellitus (DM) is a metabolic disorder that has been resulting
from a defect in insulin secretion, insulin action, or both. The main objective of this study
was joint predictors of pulse rate and time to first recovery among diabetes mellitus
patients under treatment; in case of Felege Hiwot Referral Hospital Bahir Dar, Ethiopia.
Method: A retrospective cohort study design was conducted on Diabetes Mellitus
patients selected by inclusion and exclusion criteria at Felege Hiwot Referral Hospital
under a follow-up period from April2017 to March2020. Exploratory data analysis,
Linear Mixed Model for Longitudinal Pulse Rate, Cox-Proportional hazard model for
survival part time to first recovery and joint model for the two response variables
simultaneously linked by shared random effects were used.
Results: On the sex of patients, 33.3% of the patients were male and the remaining 66.7
% patients were female. Patients with family history of disease accounted about 19 % of
total patients that means the majority patients had no family history of disease. The time
needed to reach first recovery among male patients was significantly longer compared to
female patients. Based on the result of AIC, BIC and likelihood ratio tests joint model of
longitudinal change and time to first recovery was seen to perform better than separate
models. Patients’ age, residence area, other related disease, family history of diabetes
mellitus, Systolic and Diastolic blood pressure were found to significant determinants of
pulse rate. The estimated association parameter (α) in joint model is -1.5108 and
statistically significance with (p-value<0.0001). The result indicates the higher value of
Pulse Rate was associated with the lower time to first recovery.
Conclusion: the variable age, residence area, other related disease and SBP were
common factors for longitudinal measure of Pulse Rate and time to first recovery of DM
patients. The time needed to reach first recovery among patients with no other related
disease was significantly shorter compared with patients with other related disease with
hazard ratio =0.0893. |
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