The main target of the study was to examine the effects of multimodal transport on port operation performance in Modjo dry port. Both descriptive and explanatory research design was applied and the researcher select seven target departments out of 10 by using judgmental or purposive sampling technique those are related to the topic of multimodal transport on port operation performance and proportional stratified sampling technique was used for the purpose of collecting the required data associated to the study from Modjo dry port management and employees. Questionnaire was used as a research tool for collecting data. In order to analyze, interpret and present the data captured via questionnaire, Statistical Package for the Social Sciences (SPSS) version 20 was used. The collected data was analyzed using both descriptive statistics (mean & standard deviation) and inferential statistics (correlation and multiple linear regressions). Main findings of the study depicts that, the multimodal transport dimensions has high effect on port operation performance according to the inferential analysis result (transportation management system, customer lead time, information sharing and internal integration) (i.e. All of those variables, transportation management system, customer lead time, information sharing, and internal integration had a significant effect on the operation performance of the dry port.