Patients have explicit desires or requests for services when they visit health facility. However, inadequate discovery of their needs may result in client dissatisfaction. This study aimed to determine the levels and determinants of client satisfaction with public health facility pharmacies in Bahir Dar, Ethiopia. The general objective of this study is to analyze the determinant factors affecting client satisfaction in public health facilities in Bahir Dar.Quantitative method study was conducted to determine factors affecting client satisfaction in public health pharmacies from May 20 to 30, 2021 at public health facility pharmacy in Bahir Dar. Clients fulfilling the inclusion criteria by using a five scale Likert scale questionnaire. Then data was entered and analyzed using SPSS version 23. The results of the study were presented using table, frequency, and percentage. Linear regression was also employed. In this study 389 study participants were included. Majority of the participants were females (57.1%, n = 222) with the mean age of 37. The adjusted R 2 value of the study model was 98.6, all of in dependent variables are moderately correlated, the normality test was normally distributed ,the coefficient value health facility appearance β(0.16,p=0.066),client waiting time β(-0.035 p=0.001),essential medicine availability β(0.368,p=0.000),client expectation β(0.653,p=0.000). 74.4% of clients get the prescribed essential medicines. 70.3% of clients are served with short waiting time, 72.9% clients get the expected service, and 72.8% clients are agreed on health facility appearance. And health facility appearance was statistically negatively significant effect on client satisfaction. In this study, study participants have an overall satisfaction 71.86% respondent satisfaction for essential medicine availability, client expectation is higher mean value than other determinants.