Soybean is the most important leguminous crop in Ethiopia. However, its national productivity particularly in the Northwest Ethiopia is lower than that of worlds’ productivity due to lack of appropriate agronomic practices mainly application of unbalanced fertilizer and using of inappropriate soybean varieties. Hence, a field experiment was carried out in 2020 cropping season at Guangua district, Northwest Ethiopia to determine the effect of blended NPSZnB fertilizer rates and soybean varieties on the yield, yield components and seed quality of soybean. Five levels of blended NPSZnB fertilizer (0, 50, 100, 150 and 200 kg ha-1 ) and three soybean varieties (Pawe-01, Pawe-02 and Pawe-03) were arranged in factorial and laid out in randomized complete block design with three replications. Data on soybean agronomic attributes and soybean seed quality were collected and analysed using SAS software. The result of this study revealed that the most phenological growth, yield, yield components and quality traits of soybean were significantly affected by varieties, blended fertilizer rates and their interaction effect. Planting variety pawe 03 with the application of 100 kg NPSZnB ha-1 gave the highest (2876.98 kg ha-1) grain yield and protein content (41.5%). However, the maximum (24.5%) oil content was recorded when variety pawe 01 was planted with the application of 100 kg NPSZnB ha-1 . Indeed, the partial budget analysis showed that variety pawe 03 gave the highest net benefit of 74953.56 birr ha-1 at the rate of 100 kg NPSZnB ha-1 . In conclusion, planting soybean variety of pawe 03 with the application of 100 kg NPSZnB ha-1 had significantly highest productivity and profitability of soybean and recommended for soybean production in Guangua District and similar agro ecological areas. However, the experiment was conducted for one year and in turn should be conducted in more than two years under different agro ecologies to come up with workable recommendation.