Among the viral diseases, rabies is unique and affects all warm-blooded animals which is endemic in Ethiopia. An outbreak follow-up study was undertaken from September 2019 to May 2020 in Libo Kemkem district, South Gondar Zone, Ethiopia to determine transmission dynamics of rabies outbrears in dogs. Data was collected through direct outbreak follow up and face to face interview. The transmission rate was determined using a generalized linear model (GLM) based on a susceptible-exposed-infectious-removed (SEIR) epidemic model. Basic reproduction ratio (R0) was determined from the transmission dynamics and final size of rabies outbreaks in dogs and cattle. The per day average transmission rate (β) and R0 of rabies among dogs were 0.19 and 1.15 respectively. From a total of 891 heads of cattle at risk, 115(12.9%) were affected by rabies during the outbreaks period. The highest and least values of R0 (1.11 and 1.02) were observed at Agta and Yifag kebeles respectively. Moreover, out of 279 dog bitten humans, 230 (82.4%), were treated by traditional medicine (healers), 31 (11.1%) have taken Post exposure prophylaxis (PEP) and 18 (6.5%), did nothing. Dog bitten humans were different across body parts, highest (55.9%) of bites recorded on the legs and lowest (2.2%) on the head region as compared other parts of the body. From those, five individuals (four who had followed traditional medicine and one from doing nothing) were died by rabies during the outbreaks. The herd immunity threshold level of rabies in the study area was 13% and at least more than 13% of dogs should get vaccine to overcome the outbreaks if and only if the vaccine is solid. Inconclussion, the study population were highly affected during December and February in study area. Therefore, dog vaccination at early stage of rabies outbreaks should be implemented to mitigate rabies outbreaks. Key words: Dogs, rabies outbreaks, SEIR epidemic model, transmission dynamics