A cross-sectional and longitudinal study were conducted between November 2019 to April 2020 on exotic chicken in Bahir Dar city, Northwest Ethiopia aimed to determine the incidence rate and epidemiological determinants of exotic chicken morbidity and mortality. Cluster sampling was used to select small scale chicken farms and chickens. Accordingly, a flock level questionnaire was administered to 25 small scale poultry farms. A total of 10006 exotic chickens from five small scale farms were regularly monitored for clinical health problems up to 45 days old age. Data on different potential risk factors were collected using a recording sheet and personal observations, whereas the causes of morbidity and mortality were recorded using clinical and/postmortem examination and laboratory analysis. Survival analysis using STATA 14 was employed to model the presumed explanatory variables with chicken morbidity and mortality. Accordingly, the overall incidence rate of crude exotic chicken morbidity and crude mortality risk rates were 6.58% and 6.4%, respectively. The incidence and risk rate of major chicken diseases observed were spraddle leg (15.08%, 0.99%), cannibalism (7.54%, 0.51%), ascites (6.77%, 0.46%), omphalitis (4.77%, 0.32%), avian salmonellosis (2.46%, 0.19%), avian mycoplasmas (1.08%, 0.10%), respectively. Moreover, Newcastle disease, mycoplasmas, infectious bursal disease, salmonellosis, and coccidiosis were the major economically important chicken diseases ranked by chicken farm owners. Among the risk factors investigated, the experience of the chicken caretaker (HR = 2.45, P = 0.000), source of chicken (HR = 2.64, P = 0.000), ownership of chicken caretaker (HR = 0.41, P = 0.000) and breed (HR = 2.35, P = 0.000) were found significantly associated with the incidence of crude morbidity and mortality. Serological test using SAT and ELISA was employed to confirm the suspected cases of Avian salmonellosis and Avian mycoplasmas, respectively. Among 99 sera collected from clinically diseased exotic chicken, 30.7% and 14.8% were positive for Avian salmonella and Mycoplasma galisepeticum respectively. In conclusion, the present study revealed that the incidence rate of chicken morbidity and mortality found to be higher than the economically tolerable level, which could significantly affect the productivity of small-scale chicken farms. Therefore, subsequent application interventions towards the identified determinant factors and pathogens of chicken morbidity and mortality are recommended. Keywords: Bahir Dar City, Exotic chicken, Incidence, Morbidity, Mortality, Survival analysis