In developing countries where financial resources are limited and numerous interests compete, there is a need for quantitative data on the public health burden and costs of diseases to support intervention prioritization. A retrospective study was carried out to estimate and quantify the public health and economic burden of canine rabies in Bahir Dar. Seven years data was retrieved and assessed from relevant scientific literature, from records in private and government veterinary offices and records of Bahir Dar Felege hiwot referral hospital and Bahir Dar adisalem hospital where the main Anti rabies vaccine and rabies related treatment services have been provided for Bahir Dar City. The economic burden of the disease was estimated based on costs related to PEP in humans, livestock losses, vaccination of dogs, dog birth control, stray dog control, rabies surveillance and diagnosis, and opportunity cost of the time spend on seeking treatment/vaccination. The health burden was estimated using Disability-Adjusted Life Years (DALYs) due to rabies deaths. In total, 368 animal bite cases were traced and, of which 99.18% was caused by dog bites. Annual suspected rabid dog exposures were recorded in a range of 24 - 102 bites per year, which led to about 0.38 – 0.73 deaths per 100,000 population. Generally, a total of 8 human death was recorded during the study period and this resulted in about 225.38 DALYs per 100,000 population. Cost of rabies was estimated to be 44,023.52USD and the major share of this cost was due to control measures in human amounting 16,158.04 USD. These estimations of rabies burden in the study area would provide remarkable insights to decision makers in implementing effective interventions. Key words; Bahir Dar, DALY, Economic Burden, Rabies