The primary purpose of this study was to investigate the effect of 12 weeks aerobic exercise on selected physiological variables for people with hypertension in Debre Markos town. A Subject of 17 male Debre Markos town community hypertensive patients diagnosed with hypertension more than a year were purposively selected from those hypertensive patients visited the primary care center for their monthly regular follow. Patients whose systolic blood pressure reading <140 mmHg, and diastolic blood pressure reading <89 mmHg and heat rate reading < 100 b/minute were included in the study and their age range were 36-42 years. All Selected subjects were participated in low to moderate intensity of aerobic exercise for 12 consecutive weeks, i.e., 3 days per week 30- 60-minute duration per day. Pre and post training tests were conducted on systolic and diastolic blood pressure, body mass index and resting heart rate. The data collected from the study subject was analyzed using SPSS version 23 software. The data pertaining to selected physiological variables (systolic and diastolic blood pressure, body mass index and resting heart rate) for hypertensive patients were analyzed by paired sample t-test to determine the difference between initial and final mean for ‘participant’. According to analyzed data significant net weighted reduction in systolic blood pressure by 1.647 mmHg (P<0.05), diastolic blood pressure by .412 mmHg (P<0.05), body mass index by 0.7471 (P<0.05) and resting heart rate by1.294 b/minute (P<0.05). The result obtained in this study indicated that there was significant reduction in systolic and diastolic blood pressure, body mass index and resting heart rate reading in hypertensive patients. So all hypothesizes was accepts in this study. Based on this finding, it can be concluded that Low to moderate intensity aerobic exercise has positive effect on selected physiological variables for people with hypertension Key words - Aerobic exercise, systolic and diastolic blood pressure, body mass index, resting