The purpose of the study was to investigate the relationship between organizational/internal factors and to what extent these factors affect the practice of corporate entrepreneurship in public sector organizations in case of ANRS TIMDB. The study was guided by four specific objectives. The study adopted quantitative research approach and explanatory design. The population of the research consists of the 175 employees in ANRS TIMDB at 2017. 122 employees were included by systematic sampling technique in the study. The study used primary data by using questionnaires. Frequency, percent, mean, standard deviation, correlation and regression was used in the analysis of data. The data was analyzed by using descriptive and inferential statistical tools. Internal consistency of data was checked using Cronbach Alpha Coefficient. The findings discovered that management support, organizational structure, rewards & motivation and organizational culture were found as relevant and influential factors in the practice of corporate entrepreneurial behavior of employees at ANRS TIMDB. The study further discovered that all internal factors (management support, organizational structure, rewards & motivation and organizational culture) had positive effect on corporate entrepreneurship practice at ANRS TIMDB. The study recommends that the management team be willing to accept and warmly welcome employees’ ideas and suggestions for the whole organizational performance. In order to be able to create an environment suitable for corporate entrepreneurship, ANRS TIMDB needs to know how to design its organizational structure. Rewards and motivation should be depending on employees’ innovativeness without corrupted practices and should have consistency in the Bureau. The result also shows that to develop and promote a culture of corporate entrepreneurship, encouraging the spirit of teamwork among employees, participation, flexibility and mission objectives with an emphasis on innovation, risktaking, freedom, as a factor to be considered. The study motivated the other researcher to put his/her own contribution since the public sectors service providing is not yet well strong as developed countries and need further studies on this area.